| Customization: | Available |
|---|---|
| Powder: | No |
| Customized: | Non-Customized |
|
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| Product Name | Doxycycline hyclate |
| Synonyms | 4-(DIMETHYLAMINO)-1,4,4ALPHA,5,5ALPHA,6,11,12ALPHA-OCTAHYDRO-3,5,10,12,12ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE,MONOHYDRATE;4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA;DoxycyclinemonohydrateBP200Chemicalbook0/PhEur4/USP25;DOXYCYCLINEHYDROCHLORIDE,VETRANAL;DoxycyclineHyclateUSP;DOXYCYCLINEHYCLATEUSPGRADE;(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride;DoxycyclineHydrochlocide |
| MOQ | 1kg |
| CAS | 24390-14-5 |
| Appearance | yellow to greenish-yellow |
| Molecular Formula | C22H26N2O9 |
| Molecular Weight | 462.45 |
| Assay | >99% |
| Application | For research purpose only |
| Packing | 25kg/drum |
| Storage | Store in a well-closed,light-resistant container |
| Remarks | NA |
| Custom synthesis | Available |
COA:
| Product | Doxycycline Hyclate | Packaging Size | 25kg/(Drum) |
| Tests | Acceptance Criteria | Results | Conclusion | |
Characters |
Appearance |
Yellow,crystalline powder. | Yellow, crystalline powder. | Conforms |
Solubility |
Freely soluble in water and in,sparingly soluble in ethanol(96%),dissolve in solutions of alkali hydroxides and carbonates. | 1 |
||
| Identification | A:Examine the chromatograms obtained in the assay. the retention time and size of the principal peak in the chromatogram of the test solution corresponds to that in the chromatogram of the reference solution. | Conforms |
Conforms |
|
| B:It gives reaction with sulfuric acid | Conforms | |||
| C:It gives reaction(a)of chlorides. | Conforms | |||
| pH | 2.0~3.0 | 2.5 | Conforms |
|
| Specific optical rotation | -105°~-120° (On the anhydrous and ethanol-free substance) |
-109° | Conforms | |
| Light-absorbing impuritles(490nm) |
≤0.07 (anhydrous and ethanol-free substance) |
0.01 | Conforms | |
| Specific absorbance | 300~335 (On the anhydrous and ethanol-free substance) |
312 | Conforms | |
| Tests | Acceptance Criteria | Results | Conclusion |
Related substances |
ImpurityA(6-epidoxycycline)≤2.0% | 0.60% | Conforms |
| Impurity B(metacycline)≤2.0% | 0.04% | ||
| Impurity C(4-epidoxycycline)≤0.5% | 0.1% | ||
| Impurity D(4-epi-6-epidoxycycline)≤0.5% | ND | ||
| Impurity E(Oxytetracycline)≤0.5% | ND | ||
| Impurity F(2-acetyl-2-decarbamoyldoxycycline)≤0.5% | 0.2% | ||
| Any other impurity≤0.5% | ND | ||
| Disregard limit:0.1% | |||
| E | 4.3%~6.0% | 4.8% | Conforms |
| Water | 1.4%~2.8% | 1.8% | Conforms |
| Sulphate ash | ≤0.4% | 0.03% | Conforms |
| Heavy metals | ≤50ppm | <50ppm | Conforms |
| Assay | C2HzsCINO:95.0%~102.0% (On the anhydrous and ethanol-free substance) | 98.7% | Conforms |
| Tests | Acceptance Criteria | Results | Conclusion |
Related substances |
ImpurityA(6-epidoxycycline)≤2.0% | 0.60% | Conforms |
| Impurity B(metacycline)≤2.0% | 0.04% | ||
| Impurity C(4-epidoxycycline)≤0.5% | 0.1% | ||
| Impurity D(4-epi-6-epidoxycycline)≤0.5% | ND | ||
| Impurity E(Oxytetracycline)≤0.5% | ND | ||
| Impurity F(2-acetyl-2-decarbamoyldoxycycline)≤0.5% | 0.2% | ||
| Any other impurity≤0.5% | ND | ||
| Disregard limit:0.1% | |||
| Ethanol | 4.3%~6.0% | 4.8% | Conforms |
| Water | 1.4%~2.8% | 1.8% | Conforms |
| Sulphate ash | ≤0.4% | 0.03% | Conforms |
| Heavy metals | ≤50ppm | <50ppm | Conforms |
| Assay | C2HzsCINO:95.0%~102.0% (On the anhydrous and ethanol-free substance) | 98.7% | Conforms |
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