Factory Hot Sale Top Quality Estradiol Valerate CAS 979-32-8 with Competitive Price

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Model NO.: hanways-0426
• Transport Package: 100g/Bag
• Production Capacity: 1000kg Per Month

Product Description

Estradiol valerate

delestrogen;delestrogen4x;dura-estradiol;estradiol17-beta-valerate;estradiolvalerianate;estraval;17BETA-ESTRADIOL VALERATE;17B-ESTRADIOL-17-VALERATE

979-32-8

white powder

C23H32O3

356.51

Estradiol valerate as a valerate of natural estradiol, estradiol valerate has the pharmacological effect of estrogen, can promote and regulate the normal development of female genital canal and secondary sexual characteristics, and participate in the regulation of ovarian axis function. Bioactivity Estradiolvalerate is a synthetic ester used to treat menopausal symptoms and hormone deficiencies. In vitro studies with TargetValueER enhanced phosphorylation at Ser225 in MCF-7 cells showed that Estradiol(10nM) rapidly activated SphK1, a sphingosine kinase isoenzyme. Estradiol(20nM) stimulated the rapid release of sphingosine 1-phosphate (S1P) and dihydros1p from MCF-7 cells. SphK1 and estrogen receptors are the main causes of S1P and dihydro-S1P formation. Downregulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors reduced Estradiol(10nM) -mediated S1P and dihydros1P release from MCF-7 cells. Estradiol(10nM) inhibits the expression of miR-21 in estrogen receptor-α-mediated MCF-7 human breast cancer cells. Estradiol(10nM) activated the activity of several miR-21 target gene receptors in MCF-7 cells by inhibiting the expression of miR-21. Estradiol(10nM) increased the expression of endogenous miR-21 target genes in MCF-7 cells at the protein level, but did not affect the RNA level expression. In vivo study Estradiol(80μg/kg/day,s.c.) significantly reduced the absolute number of total peritoneal cells and macrophages in ovariectomized C57BL/6J mice, characterized by double F4/80- and CD11b- positive staining. In ovariectomized C57BL/6J mice, Estradiol(80μg/kg/day,s.c.) enhanced the expression of proinflammatory cytokines in LPs-induced TGC-induced macrophages by inhibiting PI3K activity. The pro-inflammatory effect of Estradiol is eliminated by down-regulating the activity of estrogen-receptor α in thioglycolate-induced macrophages. Use for amenorrhea, menopause syndrome, reduce milk secretion, prostate cancer and so on. Use for the treatment of amenorrhea, menopause syndrome, reduce milk secretion, prostate cancer and so on
 

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